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Real-Time Imaging of the Bacillithiol Redox Potential in the Human Pathogen Staphylococcus aureus Using a Genetically Encoded Bacilliredoxin-Fused Redox Biosensor

Aims: Bacillithiol (BSH) is utilized as a major thiol-redox buffer in the human pathogen Staphylococcus aureus. Under oxidative stress, BSH forms mixed disulfides with proteins, termed as S-bacillithiolation, which can be reversed by bacilliredoxins (Brx). In eukaryotes, glutaredoxin-fused roGFP2 bi...

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Detalles Bibliográficos
Autores principales: Loi, Vu Van, Harms, Manuela, Müller, Marret, Huyen, Nguyen Thi Thu, Hamilton, Chris J., Hochgräfe, Falko, Pané-Farré, Jan, Antelmann, Haike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444506/
https://www.ncbi.nlm.nih.gov/pubmed/27462976
http://dx.doi.org/10.1089/ars.2016.6733