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Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells
The role of IL-2 in HSC maintenance is unknown. Here we show that Il2(−/−) mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2(−/−) mice. Investigation of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444691/ https://www.ncbi.nlm.nih.gov/pubmed/28415569 http://dx.doi.org/10.18632/oncotarget.16377 |