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Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells

The role of IL-2 in HSC maintenance is unknown. Here we show that Il2(−/−) mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2(−/−) mice. Investigation of...

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Detalles Bibliográficos
Autores principales:	Giampaolo, Sabrina, Wójcik, Gabriela, Serfling, Edgar, Patra, Amiya K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper: Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444691/ https://www.ncbi.nlm.nih.gov/pubmed/28415569 http://dx.doi.org/10.18632/oncotarget.16377

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