Nanocrystals of a new camptothecin derivative WCN-21 enhance its solubility and efficacy

WCN-21 is a new camptothecin derivative we synthesized and has desirable anti-tumor efficacy, but its aqueous solubility is very low and hurdles the further evaluation and development. In this study, we prepared nanocrystals of WCN-21 through a bottom-up approach to enhance its solubility and obtain...

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Detalles Bibliográficos
Autores principales: You, Jia, Chen, Yuyuan, Mohamed Alsayeh, Zubaeda M., Shen, Xingyu, Li, Chun, Zhao, Pengxuan, Chen, Fei, Liu, Yingqian, Xu, Chuanrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444705/
https://www.ncbi.nlm.nih.gov/pubmed/28423733
http://dx.doi.org/10.18632/oncotarget.16159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444705/
https://www.ncbi.nlm.nih.gov/pubmed/28423733
http://dx.doi.org/10.18632/oncotarget.16159

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