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Mass spectral analysis of the multikinase inhibitor BZG and its metabolites and analysis of their binding to vascular endothelial growth factor receptor-2

We previously showed that BZG is a novel multitarget kinase inhibitor, which inhibited hepatocellular carcinoma in vivo and in vitro. In the present study, we used ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) to characterize BZG and...

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Detalles Bibliográficos
Autores principales: Lou, Yan, Qiu, Wenqi, Wu, Zhe, Wang, Qian, Qiu, Yunqing, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444716/
https://www.ncbi.nlm.nih.gov/pubmed/28415783
http://dx.doi.org/10.18632/oncotarget.16264