Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

BACKGROUND: The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties. MATERIALS AND M...

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Detalles Bibliográficos
Autores principales: Karlsson, Henning, Fryknäs, Mårten, Strese, Sara, Gullbo, Joachim, Westman, Gunnar, Bremberg, Ulf, Sjöblom, Tobias, Pandzic, Tatjana, Larsson, Rolf, Nygren, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444738/
https://www.ncbi.nlm.nih.gov/pubmed/28415818
http://dx.doi.org/10.18632/oncotarget.16324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444738/
https://www.ncbi.nlm.nih.gov/pubmed/28415818
http://dx.doi.org/10.18632/oncotarget.16324

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