The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells

Modulation of the redox system in cancer cells has been considered a promising target for anti-cancer therapy. The novel MTH1 inhibitor TH588 proved tremendous potential in terms of cancer cell eradication, yet its specificity has been questioned by recent reports, indicating that TH588 may also ind...

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Detalles Bibliográficos
Autores principales: Aristizabal Prada, Elke Tatjana, Orth, Michael, Nölting, Svenja, Spöttl, Gerald, Maurer, Julian, Auernhammer, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444855/
https://www.ncbi.nlm.nih.gov/pubmed/28542590
http://dx.doi.org/10.1371/journal.pone.0178375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444855/
https://www.ncbi.nlm.nih.gov/pubmed/28542590
http://dx.doi.org/10.1371/journal.pone.0178375

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