Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections

In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LPV sizes and lower parasite numbers during experime...

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Detalles Bibliográficos
Autores principales: Craig, Evan, Huyghues-Despointes, Charles-Eugene, Yu, Chun, Handy, Emma L., Sello, Jason K., Kima, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444862/
https://www.ncbi.nlm.nih.gov/pubmed/28505157
http://dx.doi.org/10.1371/journal.pntd.0005556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444862/
https://www.ncbi.nlm.nih.gov/pubmed/28505157
http://dx.doi.org/10.1371/journal.pntd.0005556

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