Molecular dynamics analysis of the aggregation propensity of polyglutamine segments

Protein misfolding and aggregation is a pathogenic feature shared among at least ten polyglutamine (polyQ) neurodegenerative diseases. While solvent-solution interaction is a key factor driving protein folding and aggregation, the solvation properties of expanded polyQ tracts are not well understood...

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Detalles Bibliográficos
Autores principales: Wen, Jingran, Scoles, Daniel R., Facelli, Julio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444867/
https://www.ncbi.nlm.nih.gov/pubmed/28542401
http://dx.doi.org/10.1371/journal.pone.0178333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444867/
https://www.ncbi.nlm.nih.gov/pubmed/28542401
http://dx.doi.org/10.1371/journal.pone.0178333

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