Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

OBJECTIVE: : Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy. Reproducibl...

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Detalles Bibliográficos
Autores principales: Babaei, Hadi, Zeinalian, Mehrdad, Emami, Mohammad Hassan, Hashemzadeh, Mortaza, Farahani, Najmeh, Salehi, Rasoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444926/
https://www.ncbi.nlm.nih.gov/pubmed/28607805
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444926/
https://www.ncbi.nlm.nih.gov/pubmed/28607805
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0091

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