Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival

Type 2 transglutaminase (TG2) is an important cancer stem cell survival protein that exists in open and closed conformations. The major intracellular form is the closed conformation that functions as a GTP-binding GTPase and is required for cancer stem cell survival. However, at a finite rate, TG2 t...

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Detalles Bibliográficos
Autores principales: Kerr, Candace, Szmacinski, Henryk, Fisher, Matthew L., Nance, Bailey, Lakowicz, Joseph R., Akbar, Abdullah, Keillor, Jeffrey W., Wong, Tin Lok, Godoy-Ruiz, Raquel, Toth, Eric A., Weber, David J., Eckert, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444990/
https://www.ncbi.nlm.nih.gov/pubmed/27941875
http://dx.doi.org/10.1038/onc.2016.452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444990/
https://www.ncbi.nlm.nih.gov/pubmed/27941875
http://dx.doi.org/10.1038/onc.2016.452

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