Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in Tg...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaklamanos, Aimilios, Rozman, Jan, Roulis, Manolis, Karagianni, Niki, Armaka, Maria, Wu, Moya, Brachthäuser, Laura, Calzada-Wack, Julia, Horsch, Marion, Beckers, Johannes, Rathkolb, Birgit, Adler, Thure, Neff, Frauke, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Kollias, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445072/
https://www.ncbi.nlm.nih.gov/pubmed/28546545
http://dx.doi.org/10.1038/s41598-017-02581-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445072/
https://www.ncbi.nlm.nih.gov/pubmed/28546545
http://dx.doi.org/10.1038/s41598-017-02581-8

Ejemplares similares