Cargando…

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in Tg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaklamanos, Aimilios, Rozman, Jan, Roulis, Manolis, Karagianni, Niki, Armaka, Maria, Wu, Moya, Brachthäuser, Laura, Calzada-Wack, Julia, Horsch, Marion, Beckers, Johannes, Rathkolb, Birgit, Adler, Thure, Neff, Frauke, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Kollias, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445072/ https://www.ncbi.nlm.nih.gov/pubmed/28546545 http://dx.doi.org/10.1038/s41598-017-02581-8

Ejemplares similares

Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice
Publicado: (1994)

Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-Associated Kidney Disease
por: Horsch, Marion, et al.
Publicado: (2014)

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1(I27N) mutant mice
por: Kumar, Sudhir, et al.
Publicado: (2017)

Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI
por: Kraiger, Markus, et al.
Publicado: (2022)

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
por: Fuchs, Helmut, et al.
Publicado: (2016)

Pleiotropic Functions for Transcription Factor Zscan10
por: Kraus, Petra, et al.
Publicado: (2014)

Intranasal Human Growth Hormone (hGH) Induces IGF-1 Levels Comparable With Subcutaneous Injection With Lower Systemic Exposure to hGH in Healthy Volunteers
por: Lewis, Andrew L., et al.
Publicado: (2015)

New C3H Kit(N824K/WT) cancer mouse model develops late-onset malignant mammary tumors with high penetrance
por: Klein-Rodewald, Tanja, et al.
Publicado: (2022)

Standardized, Systemic Phenotypic Analysis of Umod (C93F) and Umod (A227T) Mutant Mice
por: Kemter, Elisabeth, et al.
Publicado: (2013)

Peroxidasin is essential for eye development in the mouse
por: Yan, Xiaohe, et al.
Publicado: (2014)

What Factors Spur a Short Individual's Response to Human GH (hGH)?
por: Rogol, Alan D
Publicado: (2023)

Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes
por: Rubio-Aliaga, Isabel, et al.
Publicado: (2009)

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection
por: Côme, Christophe, et al.
Publicado: (2016)

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice
por: Wittmann, Anke, et al.
Publicado: (2016)

Pleiotropic effects in Eya3 knockout mice
por: Söker, Torben, et al.
Publicado: (2008)

Adherence to r-hGH Therapy in Pediatric Growth Hormone Deficiency: Current Perspectives on How Patient-Generated Data Will Transform r-hGH Treatment Towards Integrated Care
por: Savage, Martin O, et al.
Publicado: (2022)

Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation
por: Vlugt-Wensink, K. D. F., et al.
Publicado: (2007)

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers
por: Deng, Tao, et al.
Publicado: (2015)

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
por: Raab, Monika, et al.
Publicado: (2011)

Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device
por: Loche, S., et al.
Publicado: (2016)

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3(L423P) Mutant Mice
por: Kumar, Sudhir, et al.
Publicado: (2016)

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction
por: Milenkovic, Dusanka, et al.
Publicado: (2022)

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice
por: Franko, Andras, et al.
Publicado: (2017)

Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring
por: Bönisch, Clemens, et al.
Publicado: (2015)

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria
por: Lucienne, Marie, et al.
Publicado: (2023)

Testosterone, cortisol, hGH, and IGF‐1 levels in an Italian female elite volleyball team
por: Roli, Laura, et al.
Publicado: (2018)

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
por: Kollmus, Heike, et al.
Publicado: (2020)

PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process
por: Diana, Jebun Nessa, et al.
Publicado: (2020)

SUN-464 Trunk Fat Increase Is Prevented Both in Patients Undergoing Long-Lasting Continuous r-hGH Therapy and in Those Who Discontinued r-hGH Compared to Untreated Patients: Results from Baseline Data of the MAGHD Study
por: Monzani, Maria Laura, et al.
Publicado: (2019)

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality
por: Sluka, Susanna H. M., et al.
Publicado: (2019)

Easypod(TM) adherence in children with growth disorders treated with r-hGH. A preliminary Italian experience
por: Loche, Sandro, et al.
Publicado: (2013)

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia
por: Vetrivel, Sharmilee, et al.
Publicado: (2019)

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice
por: Aguilar-Pimentel, Juan Antonio, et al.
Publicado: (2020)

Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice
por: Tocchetti, Arianna, et al.
Publicado: (2010)

Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine
por: Manne, Srinivasa Rao, et al.
Publicado: (2022)

PMON68 Effect of an Amino-Acid Based Blend on Human Growth Hormone (hGH) and Fibromyalgia (FM) Symptoms
por: Beres, Adam, et al.
Publicado: (2022)

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments
por: Zumbrennen-Bullough, Kimberly B., et al.
Publicado: (2014)

Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets
por: Götz, Alexander A, et al.
Publicado: (2011)

Isolation and Characterization of the Arapaima gigas Growth Hormone (ag-GH) cDNA and Three-Dimensional Modeling of This Hormone in Comparison with the Human Hormone (hGH)
por: Lima, Eliana Rosa, et al.
Publicado: (2023)

Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma
por: Wang, Jing-Jing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dnpgfr374psj12b92ujdaa2bd2