Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4

Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca(2+)-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca(2+) ions in the folding pathway. Multiple mu...

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Detalles Bibliográficos
Autores principales: Liu, Yi-Liang, Lee, Chien-Yun, Huang, Yu-Ni, Chen, Hui-Yi, Liu, Guang-Yaw, Hung, Hui-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445078/
https://www.ncbi.nlm.nih.gov/pubmed/28546558
http://dx.doi.org/10.1038/s41598-017-02677-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445078/
https://www.ncbi.nlm.nih.gov/pubmed/28546558
http://dx.doi.org/10.1038/s41598-017-02677-1

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