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Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4
Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca(2+)-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca(2+) ions in the folding pathway. Multiple mu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445078/ https://www.ncbi.nlm.nih.gov/pubmed/28546558 http://dx.doi.org/10.1038/s41598-017-02677-1 |