A Trivalent Enzymatic System for Uricolytic Therapy of HPRT Deficiency and Lesch-Nyhan Disease

PURPOSE: Because of the evolutionary loss of the uricolytic pathway, humans accumulate poorly soluble urate as the final product of purine catabolism. Restoration of uricolysis through enzyme therapy is a promising treatment for severe hyperuricemia caused by deficiency of hypoxanthine-guanine phosp...

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Detalles Bibliográficos
Autores principales: Ronda, Luca, Marchetti, Marialaura, Piano, Riccardo, Liuzzi, Anastasia, Corsini, Romina, Percudani, Riccardo, Bettati, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445154/
https://www.ncbi.nlm.nih.gov/pubmed/28508122
http://dx.doi.org/10.1007/s11095-017-2167-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445154/
https://www.ncbi.nlm.nih.gov/pubmed/28508122
http://dx.doi.org/10.1007/s11095-017-2167-6

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