Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

BACKGROUND: The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH) which renders them physiologically inert. O...

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Detalles Bibliográficos
Autores principales: McDougall, Jason J., Muley, Milind M., Philpott, Holly T., Reid, Allison, Krustev, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445456/
https://www.ncbi.nlm.nih.gov/pubmed/28545594
http://dx.doi.org/10.1186/s13075-017-1313-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445456/
https://www.ncbi.nlm.nih.gov/pubmed/28545594
http://dx.doi.org/10.1186/s13075-017-1313-1

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