Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

BACKGROUND: The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH) which renders them physiologically inert. O...

Descripción completa

Detalles Bibliográficos
Autores principales: McDougall, Jason J., Muley, Milind M., Philpott, Holly T., Reid, Allison, Krustev, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445456/
https://www.ncbi.nlm.nih.gov/pubmed/28545594
http://dx.doi.org/10.1186/s13075-017-1313-1

Ejemplares similares

Ejemplares similares