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Gene dispersion is the key determinant of the read count bias in differential expression analysis of RNA-seq data

BACKGROUND: In differential expression analysis of RNA-sequencing (RNA-seq) read count data for two sample groups, it is known that highly expressed genes (or longer genes) are more likely to be differentially expressed which is called read count bias (or gene length bias). This bias had great effec...

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Detalles Bibliográficos
Autores principales: Yoon, Sora, Nam, Dougu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445461/
https://www.ncbi.nlm.nih.gov/pubmed/28545404
http://dx.doi.org/10.1186/s12864-017-3809-0