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Gene dispersion is the key determinant of the read count bias in differential expression analysis of RNA-seq data
BACKGROUND: In differential expression analysis of RNA-sequencing (RNA-seq) read count data for two sample groups, it is known that highly expressed genes (or longer genes) are more likely to be differentially expressed which is called read count bias (or gene length bias). This bias had great effec...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445461/ https://www.ncbi.nlm.nih.gov/pubmed/28545404 http://dx.doi.org/10.1186/s12864-017-3809-0 |