Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets

Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effective targets in treating cancer. In chronic viral infections and cancer, T cells are chronic...

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Detalles Bibliográficos
Autores principales: Tsai, Hwei-Fang, Hsu, Ping-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445514/
https://www.ncbi.nlm.nih.gov/pubmed/28545567
http://dx.doi.org/10.1186/s12929-017-0341-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445514/
https://www.ncbi.nlm.nih.gov/pubmed/28545567
http://dx.doi.org/10.1186/s12929-017-0341-0

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