Topology Engineering of Proteins in Vivo Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stability

[Image: see text] Recombinant proteins are traditionally limited to linear configuration. Herein, we report in vivo protein topology engineering using highly efficient, mechanically interlocking SpyX modules named AXB and BXA. SpyX modules are protein domains composed of p53dim (X), SpyTag (A), and...

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Detalles Bibliográficos
Autores principales: Liu, Dong, Wu, Wen-Hao, Liu, Ya-Jie, Wu, Xia-Ling, Cao, Yang, Song, Bo, Li, Xiaopeng, Zhang, Wen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445526/
https://www.ncbi.nlm.nih.gov/pubmed/28573210
http://dx.doi.org/10.1021/acscentsci.7b00104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445526/
https://www.ncbi.nlm.nih.gov/pubmed/28573210
http://dx.doi.org/10.1021/acscentsci.7b00104

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