The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

OBJECTIVES: The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear diurnal rhythms. However, it is unknown whether IVD tissue contains functional circadian clocks and if s...

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Detalles Bibliográficos
Autores principales: Dudek, Michal, Yang, Nan, Ruckshanthi, Jayalath PD, Williams, Jack, Borysiewicz, Elzbieta, Wang, Ping, Adamson, Antony, Li, Jian, Bateman, John F, White, Michael R, Boot-Handford, Raymond P, Hoyland, Judith A, Meng, Qing-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446006/
https://www.ncbi.nlm.nih.gov/pubmed/27489225
http://dx.doi.org/10.1136/annrheumdis-2016-209428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446006/
https://www.ncbi.nlm.nih.gov/pubmed/27489225
http://dx.doi.org/10.1136/annrheumdis-2016-209428

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