Cargando…

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

OBJECTIVES: The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear diurnal rhythms. However, it is unknown whether IVD tissue contains functional circadian clocks and if s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dudek, Michal, Yang, Nan, Ruckshanthi, Jayalath PD, Williams, Jack, Borysiewicz, Elzbieta, Wang, Ping, Adamson, Antony, Li, Jian, Bateman, John F, White, Michael R, Boot-Handford, Raymond P, Hoyland, Judith A, Meng, Qing-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446006/ https://www.ncbi.nlm.nih.gov/pubmed/27489225 http://dx.doi.org/10.1136/annrheumdis-2016-209428

Ejemplares similares

Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway
por: Guo, B., et al.
Publicado: (2015)

(-)-Epigallocatechin-3-gallate Ameliorates Intervertebral Disc Degeneration Through Reprogramming of the Circadian Clock
por: Mei, Liangwei, et al.
Publicado: (2021)

Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm
por: Ding, Sheng-Long, et al.
Publicado: (2021)

Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein
por: Cheng, Xiaofei, et al.
Publicado: (2018)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration
por: Vadapalli, Rammohan, et al.
Publicado: (2019)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

Author Correction: Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm
por: Ding, Sheng-Long, et al.
Publicado: (2022)

The circadian rhythm in intervertebral disc degeneration: an autophagy connection
por: Zhang, Tai-Wei, et al.
Publicado: (2020)

Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration
por: Wang, Dong, et al.
Publicado: (2022)

Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage
por: Soul, Jamie, et al.
Publicado: (2018)

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
por: Purmessur, Devina, et al.
Publicado: (2008)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
por: Minogue, Ben M, et al.
Publicado: (2010)

The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2005)

Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2023)

Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
por: Tolofari, Sotonye K, et al.
Publicado: (2010)

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration
por: Kibble, Matthew J., et al.
Publicado: (2022)

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis
por: Gossan, Nicole, et al.
Publicado: (2013)

Ex Vivo Observation of Human Nucleus Pulposus Chondrocytes Isolated From Degenerated Intervertebral Discs
por: Wang, Feng, et al.
Publicado: (2011)

The U5 snRNA Internal Loop 1 Is a Platform for Brr2, Snu114 and Prp8 Protein Binding During U5 snRNP Assembly
por: Nancollis, Verity, et al.
Publicado: (2013)

Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration
por: Ligorio, Cosimo, et al.
Publicado: (2022)

Circadian time series proteomics reveals daily dynamics in cartilage physiology
por: Dudek, M., et al.
Publicado: (2021)

Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs
por: Nikolaou, Georgios, et al.
Publicado: (2017)

Development of a Unique Mouse Intervertebral Disc Degeneration Model Using a Simple Novel Tool
por: Baldia, Manish, et al.
Publicado: (2021)

Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors, and their in vivo implantation regenerated the intervertebral disc degeneration
por: Khalid, Shumaila, et al.
Publicado: (2022)

High Glucose Accelerates Autophagy in Adult Rat Intervertebral Disc Cells
por: Kong, Chae-Gwan, et al.
Publicado: (2014)

Propionibacterium acnes, Coagulase-Negative Staphylococcus, and the “Biofilm-like” Intervertebral Disc
por: Coscia, Michael F., et al.
Publicado: (2016)

Application of molybdenum target X-ray photography in imaging analysis of caudal intervertebral disc degeneration in rats
por: Su, Qi-Hang, et al.
Publicado: (2020)

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease
por: Rodrigues, Luciano Miller Reis, et al.
Publicado: (2011)

Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2
por: Hogg, Rebecca, et al.
Publicado: (2014)

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
por: Heathfield, Sarah Kathleen, et al.
Publicado: (2008)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Receptor-driven invasion profiles in diffuse intrinsic pontine glioma
por: Karki, Anju, et al.
Publicado: (2021)

The therapeutic effect of TBK1 in intervertebral disc degeneration via coordinating selective autophagy and autophagic functions
por: Hu, Sunli, et al.
Publicado: (2020)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration
por: Peng, Pandi, et al.
Publicado: (2022)

Anatomic Considerations of Intervertebral Disc Perspective in Lumbar Posterolateral Approach via Kambin's Triangle: Cadaveric Study
por: Lertudomphonwanit, Thamrong, et al.
Publicado: (2016)

Small Interfering RNA–Mediated Suppression of Fas Modulate Apoptosis and Proliferation in Rat Intervertebral Disc Cells
por: Park, Jong-Beom, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c2b8bed7khp59r4a3tb346lbdu