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Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Escherichia coli for the cognate amino acid. We measured protein synthesis rates from a reporter library of over 100 var...

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Detalles Bibliográficos
Autores principales: Ferrin, Michael A, Subramaniam, Arvind R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446239/
https://www.ncbi.nlm.nih.gov/pubmed/28498106
http://dx.doi.org/10.7554/eLife.23629