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Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria
Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Escherichia coli for the cognate amino acid. We measured protein synthesis rates from a reporter library of over 100 var...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446239/ https://www.ncbi.nlm.nih.gov/pubmed/28498106 http://dx.doi.org/10.7554/eLife.23629 |