CTCF and cohesin regulate chromatin loop stability with distinct dynamics

Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin...

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Detalles Bibliográficos
Autores principales: Hansen, Anders S, Pustova, Iryna, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446243/
https://www.ncbi.nlm.nih.gov/pubmed/28467304
http://dx.doi.org/10.7554/eLife.25776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446243/
https://www.ncbi.nlm.nih.gov/pubmed/28467304
http://dx.doi.org/10.7554/eLife.25776

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