Identification of Na(+)/K(+)-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides

The current study explored the Na(+)/K(+)-ATPase (NKA) inhibition-independent proarrhythmic mechanisms of cardiac glycosides (CGs) which are well-known NKA inhibitors. With the cytosolic Ca(2+) chelated by EGTA and BAPTA or extracellular Ca(2+) replaced by Ba(2+), effects of bufadienolides (bufalin...

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Detalles Bibliográficos
Autores principales: Koh, Cai Hong, Wu, Jianjun, Chung, Ying Ying, Liu, Zhenfeng, Zhang, Rong-Rong, Chong, Ketpin, Korzh, Vladimir, Ting, Sherwin, Oh, Steve, Shim, Winston, Tian, Hai-Yan, Wei, Heming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446409/
https://www.ncbi.nlm.nih.gov/pubmed/28550304
http://dx.doi.org/10.1038/s41598-017-02496-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446409/
https://www.ncbi.nlm.nih.gov/pubmed/28550304
http://dx.doi.org/10.1038/s41598-017-02496-4

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