Quantitative analysis of cryptic splicing associated with TDP-43 depletion

BACKGROUND: Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the ab...

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Detalles Bibliográficos
Autores principales: Humphrey, Jack, Emmett, Warren, Fratta, Pietro, Isaacs, Adrian M., Plagnol, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446763/
https://www.ncbi.nlm.nih.gov/pubmed/28549443
http://dx.doi.org/10.1186/s12920-017-0274-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446763/
https://www.ncbi.nlm.nih.gov/pubmed/28549443
http://dx.doi.org/10.1186/s12920-017-0274-1

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