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Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia, is involved in fibrotic disease, such as Syste...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447768/ https://www.ncbi.nlm.nih.gov/pubmed/28611671 http://dx.doi.org/10.3389/fphar.2017.00326 |
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author | Xiong, Anji Liu, Yi |
author_facet | Xiong, Anji Liu, Yi |
author_sort | Xiong, Anji |
collection | PubMed |
description | Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia, is involved in fibrotic disease, such as Systemic sclerosis (SSc). The implicated function of HIF-1α in fibrosis include stimulation of excessive ECM, vascular remodeling, and futile angiogenesis with further exacerbation of chronic hypoxia and deteriorate pathofibrogenesis. This review will focus on the molecular biological behavior of HIF-1α in regulating progressive fibrosis. Better understanding of the role for HIF-1α-regulated pathways in fibrotic disease will accelerate development of novel therapeutic strategies that target HIF-1α. Such new therapeutic strategies may be particularly effective for treatment of the prototypic, multisystem fibrotic, autoimmune disease SSc. |
format | Online Article Text |
id | pubmed-5447768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54477682017-06-13 Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis Xiong, Anji Liu, Yi Front Pharmacol Pharmacology Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia, is involved in fibrotic disease, such as Systemic sclerosis (SSc). The implicated function of HIF-1α in fibrosis include stimulation of excessive ECM, vascular remodeling, and futile angiogenesis with further exacerbation of chronic hypoxia and deteriorate pathofibrogenesis. This review will focus on the molecular biological behavior of HIF-1α in regulating progressive fibrosis. Better understanding of the role for HIF-1α-regulated pathways in fibrotic disease will accelerate development of novel therapeutic strategies that target HIF-1α. Such new therapeutic strategies may be particularly effective for treatment of the prototypic, multisystem fibrotic, autoimmune disease SSc. Frontiers Media S.A. 2017-05-30 /pmc/articles/PMC5447768/ /pubmed/28611671 http://dx.doi.org/10.3389/fphar.2017.00326 Text en Copyright © 2017 Xiong and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Xiong, Anji Liu, Yi Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title | Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title_full | Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title_fullStr | Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title_full_unstemmed | Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title_short | Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis |
title_sort | targeting hypoxia inducible factors-1α as a novel therapy in fibrosis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447768/ https://www.ncbi.nlm.nih.gov/pubmed/28611671 http://dx.doi.org/10.3389/fphar.2017.00326 |
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