The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca(2+) dynamics in adult mice

Heterozygous mutations in the human paired box gene PAX6 lead to impaired glucose tolerance. Although embryonic deletion of the Pax6 gene in mice leads to loss of most pancreatic islet cell types, the functional consequences of Pax6 loss in adults are poorly defined. Here we developed a mouse line i...

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Detalles Bibliográficos
Autores principales: Mitchell, Ryan K., Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Callingham, Rebecca M., Pullen, Timothy J., Cheung, Rebecca, Leclerc, Isabelle, Hodson, David J., Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448123/
https://www.ncbi.nlm.nih.gov/pubmed/28377501
http://dx.doi.org/10.1074/jbc.M117.784629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448123/
https://www.ncbi.nlm.nih.gov/pubmed/28377501
http://dx.doi.org/10.1074/jbc.M117.784629

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