Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopath...

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Detalles Bibliográficos
Autores principales: Ferrari, Michele, Jain, Isha H., Goldberger, Olga, Rezoagli, Emanuele, Thoonen, Robrecht, Cheng, Kai-Hung, Sosnovik, David E., Scherrer-Crosbie, Marielle, Mootha, Vamsi K., Zapol, Warren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448167/
https://www.ncbi.nlm.nih.gov/pubmed/28483998
http://dx.doi.org/10.1073/pnas.1621511114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448167/
https://www.ncbi.nlm.nih.gov/pubmed/28483998
http://dx.doi.org/10.1073/pnas.1621511114

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