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Estrogen receptor-dependent attenuation of hypoxia-induced changes in the lung genome of pulmonary hypertension rats

17β-estradiol (E2) exerts complex and context-dependent effects in pulmonary hypertension. In hypoxia-induced pulmonary hypertension (HPH), E2 attenuates lung vascular remodeling through estrogen receptor (ER)-dependent effects; however, ER target genes in the hypoxic lung remain unknown. In order t...

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Detalles Bibliográficos
Autores principales: Frump, Andrea L., Albrecht, Marjorie E., McClintick, Jeanette N., Lahm, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448529/
https://www.ncbi.nlm.nih.gov/pubmed/28680582
http://dx.doi.org/10.1177/2045893217702055