Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability

BACKGROUND: Hammerhead ribozymes are RNA-based molecules which bind and cleave other RNAs specifically. As such they have potential as laboratory reagents, diagnostics and therapeutics. Despite having been extensively studied for 15 years or so, their wide application is hampered by their instabilit...

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Detalles Bibliográficos
Autores principales: Hendry, Philip, McCall, Maxine J, Stewart, Tom S, Lockett, Trevor J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544870/
https://www.ncbi.nlm.nih.gov/pubmed/15588292
http://dx.doi.org/10.1186/1472-6769-4-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544870/
https://www.ncbi.nlm.nih.gov/pubmed/15588292
http://dx.doi.org/10.1186/1472-6769-4-1

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