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Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability
BACKGROUND: Hammerhead ribozymes are RNA-based molecules which bind and cleave other RNAs specifically. As such they have potential as laboratory reagents, diagnostics and therapeutics. Despite having been extensively studied for 15 years or so, their wide application is hampered by their instabilit...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544870/ https://www.ncbi.nlm.nih.gov/pubmed/15588292 http://dx.doi.org/10.1186/1472-6769-4-1 |