Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin

The chromosomal passenger complex (CPC) is a conserved, essential regulator of cell division. As such, significant anti–cancer drug development efforts have been focused on targeting it, most notably by inhibiting its AURKB kinase subunit. The CPC is activated by AURKB-catalyzed autophosphorylation...

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Detalles Bibliográficos
Autores principales: Hanley, Mariah L., Yoo, Tae Yeon, Sonnett, Matthew, Needleman, Daniel J., Mitchison, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449145/
https://www.ncbi.nlm.nih.gov/pubmed/28404751
http://dx.doi.org/10.1091/mbc.E16-12-0860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449145/
https://www.ncbi.nlm.nih.gov/pubmed/28404751
http://dx.doi.org/10.1091/mbc.E16-12-0860

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