Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remains largely unknown. Here, we show that misfolding...

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Detalles Bibliográficos
Autores principales: Zhong, Yongwang, Wang, Jiou, Henderson, Mark J, Yang, Peixin, Hagen, Brian M, Siddique, Teepu, Vogel, Bruce E, Deng, Han-Xiang, Fang, Shengyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449186/
https://www.ncbi.nlm.nih.gov/pubmed/28463106
http://dx.doi.org/10.7554/eLife.23759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449186/
https://www.ncbi.nlm.nih.gov/pubmed/28463106
http://dx.doi.org/10.7554/eLife.23759

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