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Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus
Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remains largely unknown. Here, we show that misfolding...
Autores principales: | Zhong, Yongwang, Wang, Jiou, Henderson, Mark J, Yang, Peixin, Hagen, Brian M, Siddique, Teepu, Vogel, Bruce E, Deng, Han-Xiang, Fang, Shengyun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449186/ https://www.ncbi.nlm.nih.gov/pubmed/28463106 http://dx.doi.org/10.7554/eLife.23759 |
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