Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

OBJECTIVE: The aggrecanase ADAMTS‐5 and the collagenase matrix metalloproteinase 13 (MMP‐13) are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low‐density lipoprotein receptor–related protein 1 (LRP‐1) and subsequently de...

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Detalles Bibliográficos
Autores principales: Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A., Dudhia, Jayesh, Troeberg, Linda, Itoh, Yoshifumi, Murphy, Gillian, Nagase, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449214/
https://www.ncbi.nlm.nih.gov/pubmed/28235248
http://dx.doi.org/10.1002/art.40080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449214/
https://www.ncbi.nlm.nih.gov/pubmed/28235248
http://dx.doi.org/10.1002/art.40080

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