Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR. CYP4F2 is part of the CYP4F gene cluster, which is highly polymorphic and exhibits a high degree of linkage disequilibrium, making it diffi...

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Detalles Bibliográficos
Autores principales: Zhang, J. E., Klein, Kathrin, Jorgensen, Andrea L., Francis, Ben, Alfirevic, Ana, Bourgeois, Stephane, Deloukas, Panagiotis, Zanger, Ulrich M., Pirmohamed, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449482/
https://www.ncbi.nlm.nih.gov/pubmed/28620303
http://dx.doi.org/10.3389/fphar.2017.00323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449482/
https://www.ncbi.nlm.nih.gov/pubmed/28620303
http://dx.doi.org/10.3389/fphar.2017.00323

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