Inhibition of the TRPM2 and TRPV1 Channels through Hypericum perforatum in Sciatic Nerve Injury-induced Rats Demonstrates their Key Role in Apoptosis and Mitochondrial Oxidative Stress of Sciatic Nerve and Dorsal Root Ganglion

Sciatic nerve injury (SNI) results in neuropathic pain, which is characterized by the excessive Ca(2+) entry, reactive oxygen species (ROS) and apoptosis processes although involvement of antioxidant Hypericum perforatum (HP) through TRPM2 and TRPV1 activation has not been clarified on the processes...

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Detalles Bibliográficos
Autores principales: Uslusoy, Fuat, Nazıroğlu, Mustafa, Çiğ, Bilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449501/
https://www.ncbi.nlm.nih.gov/pubmed/28620309
http://dx.doi.org/10.3389/fphys.2017.00335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449501/
https://www.ncbi.nlm.nih.gov/pubmed/28620309
http://dx.doi.org/10.3389/fphys.2017.00335

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