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Dynamic chromatin accessibility modeled by Markov process of randomly-moving molecules in the 3D genome

Chromatin three-dimensional (3D) structure plays critical roles in gene expression regulation by influencing locus interactions and accessibility of chromatin regions. Here we propose a Markov process model to derive a chromosomal equilibrium distribution of randomly-moving molecules as a functional...

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Detalles Bibliográficos
Autores principales: Wang, Yinan, Fan, Caoqi, Zheng, Yuxuan, Li, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449544/
https://www.ncbi.nlm.nih.gov/pubmed/28180283
http://dx.doi.org/10.1093/nar/gkx086