RNA–protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers

RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit HIV-1 replication, but little is known about potential aptamer-specific viral resistance. During replication, RT interacts with diverse nucleic acids. Thus, the genetic threshold for eliciting resistance may be high for aptamers that ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lange, Margaret J., Nguyen, Phuong D. M., Callaway, Mackenzie K., Johnson, Marc C., Burke, Donald H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449596/
https://www.ncbi.nlm.nih.gov/pubmed/28334941
http://dx.doi.org/10.1093/nar/gkx155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449596/
https://www.ncbi.nlm.nih.gov/pubmed/28334941
http://dx.doi.org/10.1093/nar/gkx155

Ejemplares similares