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RNA–protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers

RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit HIV-1 replication, but little is known about potential aptamer-specific viral resistance. During replication, RT interacts with diverse nucleic acids. Thus, the genetic threshold for eliciting resistance may be high for aptamers that ma...

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Detalles Bibliográficos
Autores principales:	Lange, Margaret J., Nguyen, Phuong D. M., Callaway, Mackenzie K., Johnson, Marc C., Burke, Donald H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449596/ https://www.ncbi.nlm.nih.gov/pubmed/28334941 http://dx.doi.org/10.1093/nar/gkx155

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