FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain

FASTK family proteins have been identified as regulators of mitochondrial RNA homeostasis linked to mitochondrial diseases, but much remains unknown about these proteins. We show that CRISPR-mediated disruption of FASTKD1 increases ND3 mRNA level, while disruption of FASTKD4 reduces the level of ND3...

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Detalles Bibliográficos
Autores principales: Boehm, Erik, Zaganelli, Sofia, Maundrell, Kinsey, Jourdain, Alexis A., Thore, Stéphane, Martinou, Jean-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449608/
https://www.ncbi.nlm.nih.gov/pubmed/28335001
http://dx.doi.org/10.1093/nar/gkx164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449608/
https://www.ncbi.nlm.nih.gov/pubmed/28335001
http://dx.doi.org/10.1093/nar/gkx164

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