N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Certain chemical modifications confer increased stability and low immunogenicity to in vitro transcribed mRNAs, thereby facilitating expression of therapeutically important proteins. Here, we demonstrate that N1-methyl-pseudouridine (N1mΨ) outperforms several other nucleoside modifications and their...

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Detalles Bibliográficos
Autores principales: Svitkin, Yuri V., Cheng, Yi Min, Chakraborty, Tirtha, Presnyak, Vladimir, John, Matthias, Sonenberg, Nahum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449617/
https://www.ncbi.nlm.nih.gov/pubmed/28334758
http://dx.doi.org/10.1093/nar/gkx135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449617/
https://www.ncbi.nlm.nih.gov/pubmed/28334758
http://dx.doi.org/10.1093/nar/gkx135

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