Structural basis for the D-stereoselectivity of human DNA polymerase β

Nucleoside reverse transcriptase inhibitors (NRTIs) with L-stereochemistry have long been an effective treatment for viral infections because of the strong D-stereoselectivity exhibited by human DNA polymerases relative to viral reverse transcriptases. The D-stereoselectivity of DNA polymerases has...

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Detalles Bibliográficos
Autores principales: Vyas, Rajan, Reed, Andrew J., Raper, Austin T., Zahurancik, Walter J., Wallenmeyer, Petra C., Suo, Zucai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449621/
https://www.ncbi.nlm.nih.gov/pubmed/28402499
http://dx.doi.org/10.1093/nar/gkx252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449621/
https://www.ncbi.nlm.nih.gov/pubmed/28402499
http://dx.doi.org/10.1093/nar/gkx252

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