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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
The unfolded protein response (UPR) is a stress response pathway that is activated upon increased unfolded and/or misfolded proteins in the endoplasmic reticulum (ER), and enhanced ER stress response prolongs life span and improves immunity. However, the mechanism by which ER stress affects immunity...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449662/ https://www.ncbi.nlm.nih.gov/pubmed/28559483 http://dx.doi.org/10.1128/mBio.00778-17 |