SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain

The molecular interplay between cargo recognition and regulation of the activity of the kinesin-1 microtubule motor is not well understood. Using the lysosome adaptor SKIP (also known as PLEKHM2) as model cargo, we show that the kinesin heavy chains (KHCs), in addition to the kinesin light chains (K...

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Detalles Bibliográficos
Autores principales: Sanger, Anneri, Yip, Yan Y., Randall, Thomas S., Pernigo, Stefano, Steiner, Roberto A., Dodding, Mark P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450233/
https://www.ncbi.nlm.nih.gov/pubmed/28302907
http://dx.doi.org/10.1242/jcs.198267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450233/
https://www.ncbi.nlm.nih.gov/pubmed/28302907
http://dx.doi.org/10.1242/jcs.198267

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