Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle

The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis, facilitating robust spindle assembly. However, despite a recent partial reconstitution of the human Augmin complex in vitro, the molecula...

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Detalles Bibliográficos
Autores principales: Chen, Jack W. C., Chen, Zhuo A., Rogala, Kacper B., Metz, Jeremy, Deane, Charlotte M., Rappsilber, Juri, Wakefield, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450317/
https://www.ncbi.nlm.nih.gov/pubmed/28351835
http://dx.doi.org/10.1242/bio.022905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450317/
https://www.ncbi.nlm.nih.gov/pubmed/28351835
http://dx.doi.org/10.1242/bio.022905

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