Cargando…
Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle
The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis, facilitating robust spindle assembly. However, despite a recent partial reconstitution of the human Augmin complex in vitro, the molecula...
Autores principales: | Chen, Jack W. C., Chen, Zhuo A., Rogala, Kacper B., Metz, Jeremy, Deane, Charlotte M., Rappsilber, Juri, Wakefield, James G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450317/ https://www.ncbi.nlm.nih.gov/pubmed/28351835 http://dx.doi.org/10.1242/bio.022905 |
Ejemplares similares
-
Structural insights into how augmin augments the mitotic spindle
por: Manka, Szymon W.
Publicado: (2023) -
Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules
por: Song, Jae-Geun, et al.
Publicado: (2018) -
Differing requirements for Augmin in male meiotic and mitotic spindle formation in Drosophila
por: Savoian, Matthew S., et al.
Publicado: (2014) -
Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1
por: Larsson, Veronica J., et al.
Publicado: (2018) -
Augmin-ting the central spindle
por: Short, Ben
Publicado: (2010)